Rifaximin 200mg is a derivative of the antibiotic rifamycin with minimal gastrointestinal absorption and broad-spectrum antibacterial activity covering both gram-positive and gram-negative organisms with limited cross-resistance. Beyond its antibacterial activity, such as alteration of virulence, prevention of gut mucosa! adherence and bacterial translocation, rifaximin exerts some anti-inflammatory effects with only a minimal effect on the overall composition of the gut microbiota. All these properties make Rifaximin an excellent candidate for treating various gastrointestinal diseases.
Therapeutic Fields?
Hepatic encephalopathy, prevention (off-label; treatment)
Irritable bowel syndrome without constipation
Traveler?s diarrhea, treatment (off-label; prophylaxis)
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52%
of patients saw relief from abdominal pain compared to 43% placebo
76%
of patients saw relief from diarrhea compared to 66% placebo
The global prevalence of IBS is estimated to be 11.2%, and it is the most common functional gastrointestinal disease

Dosing and Administration
Pregnancy and Breastfeeding
Due to the limited oral absorption of Rifaximin in patients, exposure to the fetus is expected to be

It is not known if Rifaximin is excreted in human milk. The risks and benefits to infants and mothers should be

Contraindications
Hypersensitivity to Rifaximin, other rifamycin antibiotics or any component of the formulation.
Warnings and Precautions

Prolonged use may result in fungal or bacterial superinfection, including Clostridioides difficile-associated diarrhea (CDAD) and pseudomembranous
Avoid use in diarrhea with fever and/or blood in the stool and treat diarrhea due to pathogens other than Escherichia
Use caution in patients with severe hepatic impairment

Drug lnteractions
Asciminib, Erdafitinib, Gilteritinib, Immune checkpoint inhibitors, Lumacaftor, lvacaftor, P-glycoprotein/ABCB1 inhibitors, Mitapivat, Typhoid vaccine, Sodium picosulfate, Bacillus clausii, Cholera vaccine, Lasmiditan, Pacritinib.
Side Effects
Peripheral edema (15%), Nausea (14%; IBS-D: 3%), Ascites (11%), Dizziness (13%), Fatigue (12%)