Specification

Sorbitrate 10mg Tablet 50?S

?Isosorbide Dinitrate 10 mg

INTRODUCTION:-
SORBITRATE 10MG contains Isosorbide dinitrate which belongs to theroup of medicines called Nitrate Vasodilators. It is used to prevent angina pectoris due to coronary artery disease and helps to control certain types of heart failure.
Angina pectoris is defined as a sudden, sharp, severe pain originating from the apex of heart and radiating to the left shoulder. The pain is severe and crushing, and it is characterized by feeling of pressure and suffocation, behind breastbone.
SORBITRATE 10MG is not recommended for use if you have anaemia, had a heart attack, bleeding in the brain, head injury, very low blood pressure, low blood volume (hypovolaemia). Before taking SORBITRATE 10MG, inform your doctor if you have any liver, kidney, heart, or thyroid problems,laucoma, or extremely low body temperature. Avoid consumption of alcohol during treatment with SORBITRATE 10MG as it may increase the risk of low blood pressure.
If you are pregnant or think you might be pregnant or planning to have a baby ask your doctor for advice before taking this medicine. SORBITRATE 10MG should be used with caution in breastfeeding women. Consult your doctor before taking it. Along with the treatment, your doctor might advice you to make certain lifestyle changes such as quitting alcohol and smoking, improve your sleep at night, eating a healthy diet and manage weight.
The most common side effects of taking SORBITRATE 10MG are headache, low blood pressure, dizziness when standing up, rapid heartbeat, drowsiness, tiredness, and swelling of the hands, ankles, or feet. Contact your doctor if any of the symptomset worse.
USES OF SORBITRATE 10MG:-
Prevents angina pectoris

Helps to control certain types of heart failure
HOW SORBITRATE 10MG WORKS:-
SORBITRATE 10MG works by relaxing the blood vessels of the heart and this reduces the strain on the heart making it easier to pump blood, thereby it provides relief from anginal symptoms.
DIRECTIONS FOR USE:-
Take SORBITRATE 10MG as advised by your physician. Swallow the medicine with alass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you based upon your age and disease condition. Do not stop taking SORBITRATE 10MG unless your doctor advises you to stop.
SIDE EFFECTS OF SORBITRATE 10MG:-

COMMON

Headache

Decrease in blood pressure, dizziness or fainting when standing up due to low blood pressure

Rapid heartbeat

Drowsiness, tiredness, weakness

Swelling of the hands, ankles?or feet

UNCOMMON

Nausea or vomiting

Skin rashes or flushing

Collapsing with slow or irregular heartbeat and fainting
Stop taking SORBITRATE 10MG and contact your doctor immediately if you experience any of the following side effects:
Signs or symptoms of cerebral ischaemia (stroke) (such as weakness in one arm or leg or one entire side of the body, slurred speech and loss of coordination)

Worsening of angina due to very low blood pressure

Allergic reaction symptoms such as rash, itching or difficulty breathing
HOW TO MANAGE SIDE EFFECTS:-

Headache:

Take rest and drink plenty of water. Try to be relaxed and stress free. Apply pain relieving balm on the forehead if necessary. Consult your doctor if the symptom does not improve.

Dizziness:

Try to rest and relax andet enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult and inform your doctor if the symptom does not improve.

Nausea or vomiting:

Try to take SORBITRATE 10MG with or just after a meal or a snack. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if the symptomets worse.
WARNING & PRECAUTIONS:-

PREGNANCY

SORBITRATE 10MG is not recommended for use during pregnancy unless considered clearly necessary. Consult your doctor before taking SORBITRATE 10MG.

BREASTFEEDING

SORBITRATE 10MG should be used with caution in breastfeeding women. Consult your doctor before taking SORBITRATE 10MG.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you experience headache, tiredness?or dizziness after taking SORBITRATE 10MG.

ALCOHOL

Avoid consumption of alcohol while taking this medicine, because it may raise the blood pressure lowering effect of this medicine.

KIDNEY

SORBITRATE 10MG should be used with caution in patients with severe kidney problems. Consult your doctor before taking SORBITRATE 10MG.

LIVER

SORBITRATE 10MG should be used with caution in patients with severe liver problems. Consult your doctor before taking SORBITRATE 10MG.

ALLERGY

Do not take SORBITRATE 10MG if you are allergic to Isosorbide dinitrate or other nitrates (such as isosorbide mononitrate, nitroglycerin) or any of the other ingredients of this medicine.

LUNGS

SORBITRATE 10MG should be used with caution in patients with impairedas exchange due to lung disease. Consult your doctor before taking SORBITRATE 10MG.

HEART DISEASE

SORBITRATE 10MG is not recommended for use in patients who had a heart attack (myocardial infarction), circulatory failure and congestive heart failure. SORBITRATE 10MG should be used with caution in heart conditions like hypertrophic obstructive cardiomyopathy (heart muscle becomes abnormally thick), constrictive pericarditis (sac-like covering of the heart (the pericardium) becomes thickened and scarred), cardiac tamponade (compression of the heart caused by fluid collecting in the sac surrounding the heart), low cardiac filling pressures, aortic/mitral valve stenosis, diseases associated with raised pressure in the head, or impairedas exchange due to ischemic heart disease. Consult your doctor before taking SORBITRATE 10MG.
OTHERS:-
SORBITRATE 10MG is not recommended for use if you:
Suffer from anaemia (reduction in red blood cells which can make the skin pale and cause weakness or breathlessness)

Had a brain haemorrhage (bleeding)

Had a head injury (trauma)

Have a low blood volume (hypovolaemia)

Have very low blood pressure
Before taking SORBITRATE 10MG inform your doctor if you:
Havelaucoma (increased pressure in the eye)

Have an underactive thyroidland

Are undernourished as a result of poor diet

Are suffering from hypothermia

Suffer from very poor circulation

Use in pediatrics:

SORBITRATE 10MG is not recommended for use in children. Consult child?s doctor for advice.

Use ineriatrics:

SORBITRATE 10MG should be used with caution in elderly patients with kidney or liver disease. Consult your doctor before taking SORBITRATE 10MG.
INTERACTIONS:-

A. Drug ? Drug interactions:

Before taking SORBITRATE 10MG, inform your doctor if you are taking any of the following medicines:
Betablockers (Ex. atenolol), calcium channel blockers (Ex. amlodipine), vasodilators (Ex. hydralazine), ACE inhibitors (Ex. enalapril) (used to treat high blood pressure)

Monoamine oxidase inhibitors such as phenelzine, selegiline and tricyclic antidepressants such as amitriptyline, amoxapine (used to treat depression)

Neuroleptics such as thioridazine, chlorpromazine (used to treat symptoms of schizophrenia)

Riociguat (used to treat pulmonary hypertension)

Phosphodiesterase inhibitors such as sildenafil, tadalafil, or vardenafil (used to treat male erectile dysfunction)

Ergotamine (used to treat migraine)

Sapropterin (used to lower phenylalanine levels in the blood)
Overdosage:
If you or anyone else accidentally takes too much of SORBITRATE 10MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are extremely low blood pressure, nausea or dizziness.
SYNOPSIS:-
Drug :?? Isosorbide dinitrate

Pharmacological Category :?? Nitrate Vasodilators

Therapeutic Indication :?? Angina pectoris,?Certain types of heart failure

Dosage Forms :?? Tablet
MORE INFORMATION:-
Keep SORBITRATE 10MG out of reach of children

Store at room temperature
FAQs ABOUT SORBITRATE 10MG:-
Can I drink alcohol during treatment with SORBITRATE 10MG?
You will be advised not to drink alcohol with SORBITRATE 10MG. Drinking alcohol or taking medicines containing alcohol with this medicine may lower your blood pressure too much or affect you more than usual.
Can SORBITRATE 10MG beiven to children?
No, SORBITRATE 10MG is not recommended for use in children. Your doctor will decide the correct dose or select a suitable alternative treatment for your child depending upon the specific disease condition
What if I forget to take a dose of SORBITRATE 10MG?
If you forget to take a dose of SORBITRATE 10MG, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not double the dose to make up for the forgotten one
Can I take sildenafil while taking SORBITRATE 10MG?
No, you should not take sildenafil along with this medicine. Both these medicines when used together it lowers the blood pressure and it can cause fainting or even a heart attack. Your doctor may prescribe alternate drug or change the interval between the drugs to prevent drug interactions in order to treat specific condition.
Is SORBITRATE 10MG safe to use in patients with kidney disease?
SORBITRATE 10MG should be used with caution in patients with severe kidney problems. Your doctor may monitor your kidney function test regularly to prevent any risk of damage to kidneys or unusual effects. Consult your doctor before taking SORBITRATE 10MG.
REFERENCES:-
1. KD. Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page ? 544-545.
2. Thomas Michel and Brian B. Hoffman. Treatment of myocardial ischemia and hypertension.oodman &ilman?s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page ? 747-750 & 752.
3.erald. Briggs and Roger K. Freeman. I. A referenceuide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page ? 2099-2100.
4. Zheng Tan, Xiaoming Shang, Li li, Luobing tian, Yi ma, Yan peng and Lingxiao. Clinical study of isosorbide mononitrate treatment for angina pectoris in coronary heart disease. NIH: National Library of Medicine, National Center for Biotechnology Information. February 2013. [Accessed on 1st August 2022]?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628368/
5. Stanley F.Malamed. Daniel L.Orr. Isosorbide Dinitrate. Medical Emergencies in the Dental Office (Seventh Edition). Science Direct. 2015. [Accessed on 1st August 2022]?https://www.sciencedirect.com/topics/medicine-and-dentistry/isosorbide-dinitrate
6. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 1st August 2022] https://www.medicines.org.uk/emc/files/pil.5795.pdf
7. Meda ManufacturingmbH. U.S. Food & Drug Administration. [Revised in January 2015] [Accessed on 1st August 2022]?https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/012093s052lbl.pdf
USEFUL DIAGNOSTIC TESTS:-
Electrocardiogram (ECG)

Chest x-ray

Chest CT

Coronary CT angiography

Cardiac MRI

Coronary angiography

Echocardiogram
PRODUCT DETAILS:-
Net Qty

1 N
Item Weight

60
Ingredient

ISOSORBIDE DINITRATE 10MG
Hsn Code

30049079

Additional information

Weight
60 g

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