INTRODUCTION
VALPOREST CR 750 TABLET contains Sodium valproate, which belongs to the group of medicines called Anti-convulsants or Anti-epileptic agents. It is used in the treatment of epilepsy (fits). Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness. Symptoms include temporary confusion, staring spells, stiff muscles, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness, fear and anxiety.
VALPOREST CR 750 TABLET is not recommended for use if you have porphyria (affecting metabolism), liver problems and Alpers-Huttenlocher syndrome (mitochondrial disorder). Before taking VALPOREST CR 750 TABLET inform your doctor if you have kidney, brain problems, carnitine palmitoyl transferase type II deficiency, diabetes and systemic lupus erythematosus (autoimmune disease).
Do not consume alcohol while taking VALPOREST CR 750 TABLET. Before taking VALPOREST CR 750 TABLET inform your doctor if you are pregnant or breastfeeding. VALPOREST CR 750 TABLET should be used with caution in children. The most common side effects of taking VALPOREST CR 750 TABLET are stomach pain, diarrhea, headache, feeling tired and weight gain. Consult your doctor if symptoms become worse while taking VALPOREST CR 750 TABLET.
USES OF VALPOREST CR 750 TABLET

Treats epilepsy (fits)

HOW VALPOREST CR 750 TABLET WORKS
VALPOREST CR 750 TABLET increases concentrations of gamma-aminobutyric acid (GABA) which reduces neuronal excitability by inhibiting nerve transmission in the brain, probably due to inhibition of the enzymes responsible for the breakdown of GABA.
DIRECTIONS FOR USE
Take VALPOREST CR 750 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
SIDE EFFECTS OF VALPOREST CR 750 TABLET

COMMON

Headache

Stomach pain

Sleepiness

Dizziness

Nausea and vomiting

Diarrhea, constipation

Weakness

Tremors (feel shaking)

Weight changes

Hair loss

Mood changes

Insomnia

Rash, nervousness

Appetite changes

Ringing sensation in ears

Blurred vision

Involuntary eye movement

Bruising or bleeding under the skin

Muscle pain

Shortness of breath

RARE
Stop taking VALPOREST CR 750 TABLET and contact your doctor immediately if you experience any of the following side effects:
An allergic reaction (rash, joint pain, fever (systemic lupus erythematosus), swallowing or breathing problems, swelling of your lips, face, throat or tongue including hands, feet or genitals, lymph node enlargement and possible impairment of other organs

Liver problems and problems of the pancreas may show as a sudden illness (nausea and vomiting many times; being very tired, sleepy and weak, stomach pain, jaundice, loss of appetite, swelling of legs and other parts of the body, worsening of fits

Skin rash or skin lesions with a pink/red ring and a pale center which may be itchy, scaly or filled with fluid (on the palms or soles of your feet, can be erythema multiforme)

Blistering or bleeding of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever (Stevens-Johnson syndrome)

Severe blistering rash where layers of the skin may peel off to leave large areas of raw exposed skin over the body, unwell, fever, chills?and aching muscles (toxic epidermal necrolysis)

Bruising more easily and getting more infections than usual (thrombocytopenia), blood clotting problems

Changes in mood, loss of memory, lack of concentration and loss of consciousness

Hypothyroidism, which may cause tiredness or weight gain

Breathing difficulty and pain due to inflammation of the lungs

Changes in behavior including being very alert?and sometimes also aggressive, hyperactive and unusual or inappropriate behavior

Changes in the amount of ammonia in the blood (symptoms include vomiting, problems with balance and co-ordination, feeling lethargic or less alert)

Sleepy or unsteady when walking or jerky muscle movements

Increase in the number and severity of convulsions

Liver damage, inflammation of the pancreas, bedwetting, renal dysfunction, overgrowth of gum tissue, aggression, agitation, disturbance in attention, abnormal behavior, hyperactivity and learning disorder in children

HOW TO MANAGE SIDE EFFECTS
Stomach pain:
Try to take rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Consult your doctor if any of your symptoms get worse or persist.
Diarrhea:
Drink a lot of fluids, such as water to keep yourself hydrated. Consult your doctor if any of your symptoms get worse or persist.
Nausea or vomiting:
Stick to simple meals. Avoid eating oily, fried or spicy foods.?Consult your doctor if any of your symptoms get worse or persist.
Headache:
Avoid bright lights, relax and take enough rest and drink more water. Apply pain-relieving balm on the forehead if necessary. Consult your doctor if any of your symptoms get worse or persist.
Dizziness:
Lie down until the dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids. Consult your doctor if any of your symptoms get worse or persist.
Constipation:
Take fiber-rich foods in your diets such as fresh fruits, vegetables and whole grain cereals and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if any of your symptoms get worse or persist.
WARNING & PRECAUTIONS

PREGNANCY
VALPOREST CR 750 TABLET is not recommended for use in pregnant women or if you are a woman of child-bearing potential you must use an effective method of contraception (birth control pill) during treatment with this medicine. Consult your doctor before taking VALPOREST CR 750 TABLET.
BREASTFEEDING
VALPOREST CR 750 TABLET should be used in breastfeeding women only if considered necessary as a very small amount of this medicine passes through breast milk, considering the benefit of breastfeeding for the child and the benefit of therapy for the woman. Consult your doctor before taking VALPOREST CR 750 TABLET.
DRIVING AND USING MACHINES
Do not drive or use machines while taking VALPOREST CR 750 TABLET as it can make you feel sleepy.
ALCOHOL
Avoid consumption of alcohol during treatment with VALPOREST CR 750 TABLET.
KIDNEY
VALPOREST CR 750 TABLET should be used with caution in patients with kidney problems. The dose will be adjusted by your doctor depending on your kidney function. Consult your doctor before taking VALPOREST CR 750 TABLET.
LIVER
VALPOREST CR 750 TABLET is not recommended for use in patients with liver problems or with a family history of liver problems. Consult your doctor before taking VALPOREST CR 750 TABLET.
ALLERGY
Do not take VALPOREST CR 750 TABLET if you are allergic to Sodium valproate or any other ingredients of this medicine.
OTHERS
VALPOREST CR 750 TABLET is not recommended for use, if you have:
Porphyria

Metabolic disorder (such as urea cycle disorder)

Genetic problem caused by a mitochondrial disorder (Alpers-Huttenlocher syndrome)
Before taking VALPOREST CR 750 TABLET, inform your doctor if you have:
Diabetes

Carnitine palmitoyl transferase type II deficiency

Brain disease or a metabolic condition affecting the brain

Systemic lupus erythematosus (SLE) (an immune system which affects skin, bones, joints and internal organs)
Use in pediatrics:
VALPOREST CR 750 TABLET should be used with caution in children. Consult your doctor before taking VALPOREST CR 750 TABLET.
Use in geriatrics:
VALPOREST CR 750 TABLET should be used with caution in the elderly. Consult your doctor before taking VALPOREST CR 750 TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking VALPOREST CR 750 TABLET, inform your doctor if you are taking any of the following medicines:
Medicines used for pain and inflammation (salicylates) (Ex. aspirin)

Other medicines used to treat fits (Ex. phenobarbital, primidone, phenytoin, carbamazepine, rufinamide, topiramate, acetazolamide, lamotrigine and felbamate)

Medicines used for thinning the blood (Ex. warfarin)

Zidovudine, lopinavir and ritonavir (used to treat HIV infection)

Temozolomide (used to treat cancer)

Monoamine oxidase inhibitors (MAOI) such as moclobemide, selegiline (used to treat depression) and linezolid (used to treat bacterial infections)

Medicines used to calm emotional and mental health problems (Ex. quetiapine, diazepam and olanzapine)

Nimodipine (used to treat bleeding in the brain)

Propofol (used as an anesthetic agent to induce sedation before surgery)

Oestrogen-containing products, including some birth control pills (used to prevent pregnancy)

Medicines used to prevent or treat malaria (Ex. mefloquine and chloroquine)

Cimetidine (used to treat stomach ulcers)

Carbapenem agents (antibiotics used to treat bacterial infections) Ex. imipenem, meropenem, rifampicin and erythromycin

Cholestyramine (used to lower cholesterol levels)

Metamizole (used to treat pain and fever)
Overdosage:
If you or anyone else accidentally take too much of VALPOREST CR 750 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea or vomiting, pupils of the eye becoming smaller, dizziness, loss of consciousness, weak muscles and poor reflexes, breathing problems, headaches, fits (seizures), confusion, memory loss and unusual or inappropriate behavior.
SYNOPSIS

Drug :?? Sodium Valproate

Pharmacological Category :?? Anti-convulsant

Therapeutic Indication :?? Epilepsy (fits)

Dosage Forms :?? Tablet, Injection, Syrup, Oral solution

MORE INFORMATION

Keep VALPOREST CR 750 TABLET out of reach from children

Store at room temperature

FAQs ABOUT VALPOREST CR 750 TABLET
What is VALPOREST CR 750 TABLET used for?
VALPOREST CR 750 TABLET is used in the treatment of epilepsy (fits) in adults and children. Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness.
Can VALPOREST CR 750 TABLET be used in pregnant women?
VALPOREST CR 750 TABLET is not recommended for use in pregnant women or if you are a woman of child-bearing potential you must use an effective method of contraception (birth control pill) during treatment with this medicine. Consult your doctor before taking VALPOREST CR 750 TABLET.
What if I miss taking a dose of VALPOREST CR 750 TABLET?
You should take VALPOREST CR 750 TABLET immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
Can I drive while taking VALPOREST CR 750 TABLET?
Do not drive or use machines while taking VALPOREST CR 750 TABLET as it can make you feel sleepy and weaken your ability to drive. Consult your doctor before taking VALPOREST CR 750 TABLET.
Can VALPOREST CR 750 TABLET be used in kidney patients?
VALPOREST CR 750 TABLET should be used with caution in patients with kidney problems. The dose will be adjusted by your doctor depending upon kidney function. Consult your doctor before taking VALPOREST CR 750 TABLET.
REFERENCES
1. KD Tripathi.?Antiepileptic Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page ? 444.
2. Pubchem. Sodium Valproate. [Accessed on 14th July 2022]?https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-valproate#:~:text=Valproate%20sodium%20is%20converted%20into,for%20the%20catabolism%20of%20GABA.
3. H. M. Emrich, D. v. Zerssen, W. Kissling, H. J. Moller and A. Windorfer. Effect of sodium valproate on mania. 1980. [Accessed on 14th July 2022]?https://link.springer.com/article/10.1007/BF00343800
4. R. M. Pinder, R. N. Brogden, T. M. Speight and G. S. Avery. Sodium Valproate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Epilepsy. November 2012. [Accessed on 14th July 2022]?https://link.springer.com/article/10.2165/00003495-197713020-00001
5. Sanofi-aventis S.A. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 14th July 2022]?https://www.medicines.org.uk/emc/files/pil.519.pdf
6. Aspire Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 14th July 2022]?https://www.medicines.org.uk/emc/files/pil.11805.pdf
USEFUL DIAGNOSTIC TESTS

Blood tests

VIDEOS

Sodium Valproate Tablet ? Drug Information
Sodium Valproate Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
Country Of Origin

India

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