Zonid suspension 200 mg 60 mL works by inhibiting the growth of bacteria and protozoa by interfering with the DNA synthesis.
Side effects
Major & minor side effects for Zonid suspension 200 mg 60 mL

Agitation

Blurred vision

Burning or tingling sensation of hands and feet

Confusion

Dizziness

Headache

Nasal congestion

Skin Rash

Bleeding gums rare

Constipation rare

Dark urine rare

Fast heartbeat rare

Uses of Zonid suspension 200 mg 60 mL
What is it prescribed for?

Amebiasis
This medicine is used for the treatment of amebiasis, a parasitic infection that affects the intestine and also for the treatment of amebic liver abscess (accumulation of pus) caused by Entamoeba histolytica.

Trichomoniasis
This medicine is used in the treatment of trichomoniasis which is a sexually transmitted disease caused by Trichomonas vaginalis.

Bacterial Vaginosis
This medicine is used in the treatment of overgrowth of bacteria in the vagina caused by Lactobacillus species.

Bacterial infections
This medicine is used to treat the infections caused by bacteria in blood, lungs, genital areas caused by Bacteroides fragilis and Clostridium species.

Peritonitis
This medicine is used in the treatment of peritonitis, which is an inflammation of the inner wall lining of the abdomen called peritoneum.

Osteomyelitis
This medicine is used in the treatment of osteomyelitis, which is an infection of the bone caused by bacteria or fungi.

Giardiasis
This medicine is used in the treatment of giardiasis, which is an infection of the small intestine caused by giardia.

Sexually transmitted diseases prophylaxis
This medicine is used in the prevention of diseases which may be transmitted sexually.

Concerns

Frequently asked questions

Onset of action
The effect of this medicine can be observed within 2 hours of administration of the dose.

Duration of Effect
The amount of time for which this medicine remains active in the body is not clinically established.

Safe with Alchohol?
Consumption of alcohol is not recommended in patients with Zonid suspension 200 mg 60 mL. Any symptoms of the fast heartbeat, warmth, headache, and breathing difficulty should be reported to the doctor.

Is it habit forming?
No habit-forming tendencies were reported.

Usage in pregnancy?
This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed. All the risks and benefits should be discussed with the doctor before taking this medicine.

Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition

When not to use?

Allergy
Not recommended in patients with known allergy to Zonid suspension 200 mg 60 mL or other nitroimidazoles.

Warnings

Warnings for special population

Pregnancy
This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed.

Breast-feeding
This medicine is known to excreted through the breastmilk. It is used in breastfeeding women only if clearly needed. Breastfeeding should be avoided for 24 hours after single-dose maternal treatment. Monitoring of candidal infections and diarrhea is necessary.

General Warnings

Blood cell count
This medicine may lower the blood cell count and may lead to leukopenia, thrombocytopenia, and bone marrow aplasia. Close monitoring of WBC count, platelets is necessary. Discontinue the treatment if any signs of low blood cell count appear.

Neurologic Toxicity
This medicine may cause neurological effects like convulsions and peripheral neuropathy. Inform the doctor if you have any neurological problems. Any symptoms of convulsions, tingling or burning sensation of hands and feet should be reported to the doctor.

Impaired liver function
This medicine may cause liver injury. The baseline of liver enzymes should be obtained before initiating the therapy. Any signs of elevation in the liver enzymes should be informed to the doctor. Discontinue the treatment until the levels reach to normal.

Dialysis
The desired effect of this medicine is not achieved in dialysis patients. It is necessary to schedule the dose for administration after dialysis procedure or supplemental doses can be given after dialysis

Chronic therapy
This medicine should not be used unnecessarily unless instructed by the doctor because it can increase the risk of developing resistance to this medicine and it can increase the risk of additional infections.

Driving or Operating machinery
Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Dosage

Missed Dose
If you miss a dose of Zonid suspension 200 mg 60 mL, take the missed dose as soon as you remember. If it?s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions
Interaction with Medicines

Warfarin severe

Ethinyl Estradiol moderate

Atorvastatin moderate

Disulfiram moderate

Phenytoin moderate

Lithium moderate

Disease interactions

severe
This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, due to the increased risk of worsening of the patient’s condition. Report any incidence of severe or persistent diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

severe
This medicine should be used with caution in patients with low blood counts or bone marrow depression due to the increased risk of leukopenia, thrombocytopenia, etc. Regular monitoring of complete blood count is necessary for such patients. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

severe
This medicine should be used with caution since it may increase the risk of nervous system toxicity which may include convulsions and peripheral neuropathy. Report any symptoms of numbness, tingling or burning sensation of hands and feet to doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

severe
This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

General Instructions

Take Zonid suspension 200 mg 60 mL as advised by your doctor. Do not take in larger amounts than advised. It is advised to take this medicine at the same time every day. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.

Other details

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

References

practo.com –
Metronidazole [Internet].
Available from: https://www.practo.com/medicine-info/metronidazole-182-api
[cited 31 August 2019].
16 Nov 2017

medlineplus.gov –
Metronidazole Injection [Internet].
Available from: https://medlineplus.gov/druginfo/meds/a601159.html
[cited 31 August 2019].
22 July 2019

https://dailymed.nlm.nih.gov –
METRONIDAZOLE [Internet].
Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a66abf44-9ae9-4342-b69a-ebaa1f9b7d78
[cited 31 August 2019].
November 27, 2006