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Histalex 100 mlHistalex 100 ml is indicated in the following indications- Urticaria Sensitivity reactions Angioneurotic edema Vasomotor rhinitis Cough Common cold Motion sickness and Other allergic conditions. Theropeutic ClassSedating Anti-histaminePharmacologyChlorpheniramine is an alkylamine antihistamine. It is one of the most potent H1 blocking agents and is generally effective in relatively low doses. Chlorpheniramine is not so prone to produce drowsiness, readily absorbed from the gastro-intestinal tract, metabolised in the liver and excreted usually mainly as metabolised in the urine.Dosage & Administration of Histalex 100 mlAdults: 4 mg 3-4 times daily.Children: Up to 1( one) year: 1 mg twice daily 1-5 years: 1 mg 3-4 times daily 6-12 years: 2 mg 3-4 times daily or as directed by the physician Dosage of Histalex 100 mlAdult- Usual adult dose is 4 mg every 4-6 hours, maximum 24 mg daily. Child- 6-12 years: 2 mg every 4-6 hours, maximum 12 mg daily. 2-5 years: 1 mg every 4-6 hours, maximum 6 mg daily. 1-2 years: 1 mg twice daily. Below 1 year the use of Histalex 100 ml is not recommended.Interaction of Histalex 100 mlChlorphenamine maleate has been reported to be incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium, and meglumine adipiodone.ContraindicationsChlorpheniramine is contraindicated in patients hypersensitive to this agent, in newborn or premature infants.Side Effects of Histalex 100 mlChlorpheniramine is well-tolerated, but sometimes drowsiness, dizziness, muscular weakness, and gastrointestinal upset may occur.Pregnancy & LactationPregnancy?Category B.?Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).Precautions & WarningsChlorpheniramine should be used with caution in patients with glaucoma and prostatic hypertrophy. During therapy with chlorpheniramine, caution should be taken in driving vehicles and operating machinery.Overdose Effects of Histalex 100 mlCNS depression (including sedation, apnea, CV collapse), CNS stimulation (including insomnia, hallucination, tremors, convulsions), tinnitus, blurred vision, dizziness, ataxia, hypotension. Stimulation and atropine-like signs and symptoms (including dry mouth, fixed dilated pupils, flushing, hyperthermia, Gl symptoms) are more likely in children.Storage ConditionsStore in a cool (Below 25?C temperature) and dry place protected from light. Keep out of the reach of children.Drug ClassesSedating Anti-histamineMode Of ActionHistalex 100 ml is an alkylamine antihistamine. It is one of the most potent histamine H1-receptor blocking agents which is used as a potent antihistamine. This generally causes less sedation than promethazine. Histalex 100 ml exerts its effects by blocking H1-receptor competitively.PregnancyThis drug should not be used in lactating mother and in pregnancy especially during the first trimester of pregnancy.