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Lacticon 10 gm/sachetLacticon 10 gm/sachet is indicated in chronic idiopathic constipation (CIC), acute and chronic portal systemic encephalopathy.Theropeutic ClassOsmotic purgativesPharmacologyLacticon 10 gm/sachet is a disaccharide derivatives consisting of galactose and sorbitol, which is only minimally absorbed and is not hydrolysed by the disaccharidases of the GIT and thus reaches the colon unchanged. In the colon it is broken down to short chain low molecular weight organic acids by the intestinal flora, resulting in an increase in osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume, which explains the laxative effect. Lacticon 10 gm/sachet produces its effect in the lumen of the colon, where it is virtually 100% bioavailable. It is absorbed only in minimal amounts. Up to 2% can be found unchanged in the urine.Dosage & Administration of Lacticon 10 gm/sachetLactitol can be mixed with hot or cold beverages, puddings etc. Dosage will require adjustment to obtaine one daily bowel movement in constipated patients and two daily bowel movements in patients with portal systemic encephalopathy. In constipation: In adult: The initial daily dosage should be 20 g taken in a single dose with the morning or evening meal. After a few days, a daily dose of 10 g may be sufficient. Children: The mean dosage is 0.25 g/kg body weight daily. 1 to 6 years: 2.5 to 5 gm 6 to 12 years: 5 to 10 gm 12 to 16 years: 10 to 20 gm The effect of lactitol has been found mostly to occur within a few hours after intake. But in some cases the first laxative response may be delayed until the second or third day of administration. Therefore patients should be advised to maintain an adequate daily fluid intake. In portal systemic encephalopathy: The dose should be adjusted according to the severity of the patient?s disease and their individual response. The initial recommended dose is 0.5 to 0.7 gm/kg body weight daily, divided into three daily doses with meals.Dosage of Lacticon 10 gm/sachetLactitol can be mixed with hot or cold beverages, puddings etc. Dosage will require adjustment to obtaine one daily bowel movement in constipated patients and two daily bowel movements in patients with portal systemic encephalopathy. In constipation: In adult: The initial daily dosage should be 20 g taken in a single dose with the morning or evening meal. After a few days, a daily dose of 10 g may be sufficient. Children: The mean dosage is 0.25 g/kg body weight daily. 1 to 6 years: 2.5 to 5 gm 6 to 12 years: 5 to 10 gm 12 to 16 years: 10 to 20 gm The effect of lactitol has been found mostly to occur within a few hours after intake. But in some cases the first laxative response may be delayed until the second or third day of administration. Therefore patients should be advised to maintain an adequate daily fluid intake. In portal systemic encephalopathy: The dose should be adjusted according to the severity of the patient?s disease and their individual response. The initial recommended dose is 0.5 to 0.7 gm/kg body weight daily, divided into three daily doses with meals.Interaction of Lacticon 10 gm/sachetAntacids and neomycin should not be given simultaneously with Lactitol to cirrhotic patients with portal systemic encephalopathy. Lactitol may increase potassium loss caused by other drugs e.g. thiazide diuretics, corticosteroids, carbenoxolone, amphotericin B and it may enhance the risk of toxic effects of glycosides in patients receiving concomitant therapy.ContraindicationsPatients with known hypersensitivity to any of the ingredients of this preparation.Side Effects of Lacticon 10 gm/sachetAt the start of the treatment with lactitol may produce abdominal discomforts such as flatulence, pain, cramps or sensation of fullness. Such effects tend to diminish or disappear after a few days of regular intake of Lactitol. Occasionally, nausea or anal pruritus has been reported in some cases.Pregnancy & LactationLactitol is minimally absorbed systemically following oral administration, and it is unknown whether maternal use will result in fetal exposure to the drug. There are no data on the presence of lactitol in human or animal milk, the effects on the breastfed infant, or the effects on milk production.Precautions & Warnings Elderly or debilitated patients receiving long-term treatment with lactitol should have their serum electrolytes monitored regularly. As for all laxatives, pre-existing fluid or electrolyte imbalance should be corrected before starting treatment with lactitol. Following treatment of Lactitol, hydrogen may accumulate in the bowel. Patients who need to undergo electrocauterisation procedure should therefore have a thorough bowel cleansing with a non-fermentable solution. Lactitol is not recommended in case s of ileostomy or colostomy. Prolonged use of laxatives without interruption should be avoided. Storage ConditionsStore in a cool, dry place and away from light. Keep out of reach of children.Drug ClassesOsmotic purgativesMode Of ActionLacticon 10 gm/sachet is a disaccharide derivatives consisting of galactose and sorbitol, which is only minimally absorbed and is not hydrolysed by the disaccharidases of the GIT and thus reaches the colon unchanged. In the colon it is broken down to short chain low molecular weight organic acids by the intestinal flora, resulting in an increase in osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume, which explains the laxative effect. Lacticon 10 gm/sachet produces its effect in the lumen of the colon, where it is virtually 100% bioavailable. It is absorbed only in minimal amounts. Up to 2% can be found unchanged in the urine.PregnancyLactitol is minimally absorbed systemically following oral administration, and it is unknown whether maternal use will result in fetal exposure to the drug. There are no data on the presence of lactitol in human or animal milk, the effects on the breastfed infant, or the effects on milk production.