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Anfree 0.5 mg+10 mgAnfree 0.5 mg+10 mg tablet is indicated in- Anxiety Depression Apathy Psychogenic depression. Depressive neurosses. Masked depression. Psychosomatic affections accompanied by anxiety and apathy. Menopausal depressions. Dysphoria and depression in alcoholics and drug addicts.Theropeutic ClassCombined anxiolytics & anti-depressant drugsPharmacologyMaximum serum concentration is reached in about 4 hours after oral administration of Anfree 0.5 mg+10 mg. The half-life of Flupentixol is about 35 hours and that of Melitracen is about 19 hours. The combination of Flupentixol and Melitracen does not seem to influence the pharmacokinetic properties of the individual compounds. Flupenthixol primarily acts as a neuroleptic drug. The antipsychotic effect of Flupenthixol is achieved by mixed blockade of dopamine D1 and D2 receptors. In the mesolimbic dopamine system of the brain, this accounts for the antipsychotic action of this drug. Flupenthixol has other effects on CNS. In the chemoreceptor trigger zone, the dopamine blockade accounts for the antiemetic effect of the drug.Melitracen is a tricyclic antidepressant. It blocks the neuronal re-uptake of both serotonin and nor-epinephrine in the central nervous system, there by minimizing the symptoms of depression.Dosage & Administration of Anfree 0.5 mg+10 mgAdults: Usually 2 tablets daily, in morning and afternoon. In severe cases, the morning dose may be increased to 2 tablets.Elderly patients: 1 tablet in the morning. Maintenance dose: Usually 1 tablet in the morning or as directed by the physician.Dosage of Anfree 0.5 mg+10 mgAdults: Usually 2 tablets orally daily in the morning and noon. In severe cases, the morning dose may be increased to 2 tablets.Elderly patients: 1 tablet in the morning. Maintenance dose: Usually 1 tablet orally in the morning. In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended.Interaction of Anfree 0.5 mg+10 mgThis tablet may enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.ContraindicationsThe immediate recovery phase after myocardial infarction. Defects in bundle-branch conduction. Untreated narrow-angle glaucoma. Acute alcohol, barbiturate and opiate intoxications. This tablet should not be given to patients who have received an MAO-inhibitor within two weeks. Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics.Side Effects of Anfree 0.5 mg+10 mgIn the recommended doses side effects are rare. These could be transient restlessness and insomnia.Pregnancy & LactationThe safety of this drug has not been established in pregnancy and lactation.Precautions & WarningsIf previously the patient has been treated with tranquillizers with sedative effect these should be withdrawn gradually.Overdose Effects of Anfree 0.5 mg+10 mgIn cases of overdosage the symptoms of intoxications by melitracen, especially of anticholinergic nature, dominate. More rarely extrapyramidal symptoms due to flupentixol occur. Symptomatic and Supportive. Gastric lavage should be carried out as soon as possible and activated charcoal may be administered. Measures aimed at supporting the respiratory and cardiovascular systems should be instituted. Epinephrine (adrenaline) must not be used for such patients. Convulsions may be treated with diazepam and extrapyramidal symptoms with biperiden.Storage ConditionsStore at a temperature not exceeding 30?C in a dry place. Protect from light. Keep out of reach of children.Drug ClassesCombined anxiolytics & anti-depressant drugsMode Of ActionThis consists of two well known and well proven compounds: flupentixol-a neuroleptic with anxiolytic and antidepressant properties of its own when given in small doses, and melitracen-a bipolar thymoleptic with activating properties in low doses. In combination the compounds render a preparation with antidepressant, anxiolytic and activating properties. Maximal serum concentration is reached in about 4 hours after oral administration of flupentixol and in about 4 hours after oral administration of melitracen. The biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours. The combination of Anfree 0.5 mg+10 mg does not seem to influence the pharmacokinetic properties of the individual compounds.PregnancyThis tablet should preferably not be given during pregnancy and lactation.