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Pevisone 1%+0.1%Econazole Nitrate & Triamcinolone Acetonide indicated for the treatment of: Eczematous Mycoses Psoriasis Tinea Pedis (Athlete?s foot) Tinea Corporis (Ring worm) Tinea Cruris (Jock itch) Inflammatory Intertrigo Diaper Dermatitis ... Read moreEconazole Nitrate & Triamcinolone Acetonide indicated for the treatment of: Eczematous Mycoses Psoriasis Tinea Pedis (Athlete?s foot) Tinea Corporis (Ring worm) Tinea Cruris (Jock itch) Inflammatory Intertrigo Diaper Dermatitis Onychomycoses- for the treatment of onychomycoses, local therapy with Econazole/Triamcinolone cream, combined with an oral antimycotic, is recommended.Theropeutic ClassTriamcinolone & Combined preparationsPharmacologyEconazole Nitrate: Econazole modifies the permeability of cell wall membrane in fungi; may interfere with RNA and protein synthesis, and lipid metabolism.Triamcinolone has mainly glucocorticoid activity. It suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability thereby decreasing inflammation.Dosage & Administration of Pevisone 1%+0.1%Adults: Apply twice daily to the affected area and rub on the skin gently with the finger. Continue the applications for 14 days or as directed by the doctor.Children: Suitable for topical application to children.For topical administration only.Dosage of Pevisone 1%+0.1%Adults: This cream should be applied sparingly to the skin lesion no more than 2 times daily, preferably once in the morning and once in the evening. This cream should not be applied with an occlusive dressing, or to large areas of skin on the body. The duration of treatment with this cream should continue until the inflammatory symptoms subside but not longer than 2 weeks; after 2 weeks of therapy with this cream, continue therapy as needed with a preparation containing econazole or econazole nitrate alone.Pediatric Use: Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing's syndrome than mature patients because of a larger skin surface area to body weight. Caution should be exercised.Interaction of Pevisone 1%+0.1%Econazole: compound metabolized by CYP3A4/2C9 oral anticoagulants (warfarin & acenocoumarol).Triamcinolone: lowering of plasma salicylates levels. Increased risk of Gl bleeding and ulceration with NSAIDs. Antagonised blood glucose-lowering effects of the antidiabetics. Increased risk of Hyperkalemia with amphotericin B, beta-blockers, potassium-depleting diuretics, theophylline. Increased clearance of the triamcinolone with ciclosporin, carbamazepine, phenytoin, barbiturate, rifampicin.ContraindicationsThis Cream is contraindicated- In individuals who have shown hypersensitivity to any of its ingredients. Like any other dermatological preparation containing corticosteroids, this Cream is contraindicated in specific skin conditions such as tuberculous, varicella, herpes simplex or other viral infections of the skin, or fresh vaccination sites. Decubitus ulcers: Viral, bacterial or fungal skin infections (e.g. tuberculosis of the skin, syphilis of the skin, herpes simplex, herpes zoster, chickenpox). Rosacea and rosacea-like dermatitis. Side Effects of Pevisone 1%+0.1%Rarely, transient local mild irritation, itching & redness may occur immediately after application. Econazole has the minimal allergenic effect and is well tolerated, even by delicate skin. Adrenal suppression on long term continuous topical steroid therapy may occur, particularly in infants or children, or when occlusive dressings are applied. It should be noted that an infant's napkin may act as an occlusive dressing.Pregnancy & LactationPregnancy: Not the Econazole but the Triamcinolone Acetonide crosses the placenta and topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development. The relevance of this finding to human beings has not been established. However, topical steroids in large amounts or for prolonged periods should not be used in pregnancy.Lactation: Negligible amount of econazole and to some extent Triamcinolone may be excreted in small amounts in breast milk. So, this cream should not be prescribed to the lactating mother or if prescribed lactation should be withheld during treatment.Precautions & Warnings For external use only. This Cream is not for ophthalmic or oral use. If a reaction suggesting hypersensitivity or chemical irritation should occur, use of the medication should be discontinued. Corticosteroids applied to the skin can be absorbed in sufficient amounts to produce systemic effects, including adrenal suppression. Systemic absorption may be increased by various factors such as application over a large skin surface area, application to damaged skin, application under occlusive skin dressings and prolonged duration of therapy. Topical corticosteroids are associated with skin thinning and atrophy, striae, telangiectasis and purpura. Topical corticosteroids may lead to increased risk of dermatological superinfection or opportunistic infection. Children: Increased caution is required when treating children. Compared to adults, the nature of a child's skin and the larger skin surface area relative to body weight may lead to an increased absorption of the corticosteroid via the child's skin. This cream should be used in children only for short periods of time (less than 2 weeks) and on small areas (less than 10% of body surface area).Visual disturbance may be associated with systemic and topical corticosteroid use. If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR).Overdose Effects of Pevisone 1%+0.1%This Cream is for cutaneous application only. Corticosteroids applied to the skin, including triamcinolone, can be absorbed in sufficient amounts to produce systemic effects. In the event of accidental ingestion, treat symptomatically. If this cream is accidentally applied to the eyes, wash with clean water or saline and seek medical attention if symptoms persist.Storage ConditionsStore in a cool (below 30?C) and dry place, away from light. Keep out of the reach of children.Drug ClassesTriamcinolone & Combined preparationsPregnancyPregnancy: Not the Econazole but the Triamcinolone Acetonide crosses the placenta and topical administration of corticosteroids during pregnancy can cause abnormalities of foetal development. The relevance of this finding to human beings has not been established. However, topical steroids in large amounts or for prolonged periodsshould not be used in pregnancy.Lactation: Negligible amount of econazole and to some extent Triamcinolone may be excreted in small amounts in breast milk. So this cream should not be prescribed to the lactating mother or if prescribed lactation should be withheld during treatment.