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Daflon 1000 mgIt is indicated in the treatment of- Acute hemorrhoidal attacks. Chronic hemorrhoidal disease. Organic and functional chronic venous insufficiency of the lower limbs with the following symptoms: heavy legs, pain, nocturnal cramps. Theropeutic ClassPhlebotonic & Vascular protecting preparationPharmacologyDiosmin and Hesperidin is a phlebotonic drug and a vascular protecting agent. It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus Diosmin and Hesperidin decreases venous capacitance, venous distensibility, and venous emptying time. Diosmin and Hesperidin protects the microcirculation by fighting the microcirculation damaging process; It combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandin. Thus Diosmin and Hesperidin normalizes capillary permeability and strengthens capillary resistance. Diosmin and Hesperidin acts on the lymphatic system, It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure.Dosage & Administration of Daflon 1000 mgTablet should be taken at meal times.Acute hemorrhoidal attacks: 3 tablets twice daily for the first 4 days, then 2 tablets twice daily for three days and if required 1 tablet twice daily as maintenance dosage.Chronic hemorrhoids: 1 tablet twice daily.Chronic venous insufficiency: 1 tablet twice daily initially for seven days. Duration may be increased depending on severity.Interaction of Daflon 1000 mgProper data is not available.ContraindicationsProper data on contraindication is not available.Side Effects of Daflon 1000 mgSome cases of routine gastric disorders and neurovegetative disorders (feeling of discomfort) have been reported. In this cases discontinuation of treatment is not required.Pregnancy & LactationExperimental studies in animal have not demonstrated any teratogenic effects and no harmful effect have been reported in women to date. Breast feeding is not recommended during treatmentPrecautions & WarningsIf the hemorrhoidal symptoms do not disappear within 15 days, patient should ask doctor for advice.Storage ConditionsKeep below 30?C temperature, away from light & moisture. Keep out of the reach of children.