This medicine works by slowing the production of certain substances that cause an acne breakout.
Side effects
Major & minor side effects for Isoface tablet 20 mg 10?s

Changes in skin color rare

Bleeding from nose rare

Scaling, burning, redness, and swelling of skin

Burning, dry and itchy eyes rare

Itchy and dry skin

Bleeding or swollen gums rare

Changes in the nail color rare

Hair loss rare

Sweating rare

Ringing or buzzing in the ears rare

Uses of Isoface tablet 20 mg 10?s
What is it prescribed for?

Nodular acne
This medicine is used for the treatment of a severe form of acne called nodular acne characterized by large, inflamed, painful acne lesions deep under the skin. It is used in patients who have not responded adequately to therapy with systemic antibacterials and topical therapy.

Concerns

Frequently asked questions

Onset of action
The effect of this medicine can be observed within 2-4 weeks of topical application.

Duration of Effect
The time duration for which this medicine remains effective is not clinically established.

Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?
No habit forming tendencies were reported.

Usage in pregnancy?
Use of this medicine by women are pregnant or suspecting a pregnancy is not recommended. It is advised to take extra precautionary measures and avoid intended/unintended pregnancy while using this medicine.

Usage while breast-feeding?
Use of this medicine by women who are breastfeeding is not recommended. Your doctor may prescribe suitable alternatives after assessing your condition.

When not to use?

Allergy
This medicine is not recommended for use if you have a known history of allergy to tretinoin/Isoface tablet 20 mg 10?s /retinoids or any other component present in the dosage form.

Hypervitaminosis A
This medicine is not recommended for use if you have more than normal levels of vitamin A in the body.

Warnings

Warnings for special population

Pregnancy
Use of this medicine by women are pregnant or suspecting a pregnancy is not recommended. It is advised to take extra precautionary measures and avoid intended/unintended pregnancy while using this medicine.

Breast-feeding
Use of this medicine by women who are breastfeeding is not recommended. Your doctor may prescribe suitable alternatives after assessing your condition.

General Warnings

Exposure to sun
Use of this medicine can cause adverse reactions of the skin on sun exposure. You should either avoid stepping out at daytime or take appropriate precautionary measures.

Contraception
Appropriate means of birth control should be adopted while using this medicine. It can cause oral/hormonal contraception failure and hence use of multiple contraception is advised. Contact your doctor immediately if you suspect a pregnancy while using this medicine.

Donation of blood
It is advised to refrain from donating blood for 1 month after stopping the use of this medicine.

Diabetes
This medicine may alter the blood glucose levels and hence should be used with extreme caution in patients with diabetes mellitus. Close monitoring of the blood glucose levels, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Hearing impairment
Use of this medicine has been associated with hearing impairment which may persist even after the use is discontinued.

Disturbance in vision
Use of this medicine may cause disturbances in vision. Report any incidence of disturbance in the vision to the doctor.

Hyperlipidemia
This medicine has been associated with an increased level of lipids and triglycerides in the body and hence should be used with caution in patients suffering from hypercholesterolemia and other associated diseases. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or operating machinery
This medicine may rarely cause dizziness, drowsiness, visual disturbances, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.

Dosage

Missed Dose
Skip the missed dose and continue with the regularly scheduled dose. Do not take extra medicine to make up for the missed dose.

Overdose
Contact a doctor immediately if an overdose with this medicine is suspected. Symptoms of overdose may include a headache, dizziness, vomiting, stomach pain, tingling and stinging sensation of the skin etc.

Interactions
Interaction with Medicines

Tetracycline severe

Methoxsalen moderate

Medroxyprogesterone moderate

Doxycycline severe

Daclizumab severe

Disease interactions

severe
This medicine is not recommended for use in patients having increased pressure around the brain due to the risk of worsening of the patient’s condition. Report any unusual symptoms such as a headache, nausea, vomiting, visual disturbances, etc. to the doctor immediately. Replacement with a suitable alternative should be considered based on the clinical condition.

moderate
This medicine should be used with extreme caution in patients with preexisting psychiatric conditions or depression due to the risk of worsening of the patient’s condition. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

moderate
This medicine may cause a reduction in bone density and hence should be used with caution in patients suffering from osteoporosis or other disorders affecting bone density. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

moderate
This medicine should be used with extreme caution in patients with liver diseases due to the risk of worsening the patient’s condition. Report any unusual symptoms to the doctor immediately. Close monitoring of the liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Lab interactions

General Instructions

Take Isoface tablet 20 mg 10?s as instructed by the doctor. Follow all the directions mentioned on the label. Do not take in larger or smaller quantities than prescribed. This medicine should be taken with food. The symptoms might get worse in the initial phase of treatment.

Other details

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

References

practo.com –
Isotretinoin [Internet].
Available from: https://www.practo.com/medicine-info/isotretinoin-148-api
[cited 20 september 2019].
16 Nov 2017

dailymed.nlm.nih.gov –
Isotretinoin [Internet].
Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3ef0cff8-19c1-4441-b780-fca6c7ee1615
[cited 20 september 2019].
November 2, 2018

medlineplus.gov/druginfo/meds –
Isotretinoin [Internet].
Available from: https://medlineplus.gov/druginfo/meds/a681043.html
[cited 20 september 2019].
11 September 2019